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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | OAVG | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Sandy Koufax* | .2010 | 1955-1966 | |
| 2 | Sam McDowell | .2023 | 1961-1979 | |
| 3 | Marcos Ortega# | .2043 | 1976-1981 | |
| 4 | Lowell Palmer | .2062 | 1968-1979 | |
| 5 | Tom M Carroll# | .2080 | 1974-1981 | |
| 6 | Rudy May | .2083 | 1965-1976 | |
| 7 | Ed Walsh* | .2087 | 1904-1917 | |
| 8 | Smoky Joe Wood | .2089 | 1908-1920 | |
| 9 | Babe Ruth* | .2100 | 1914-1935 | |
| 9 | Ed Reulbach | .2100 | 1905-1917 | |
| 9 | Bob Turley | .2100 | 1951-1963 | |
| 12 | Orval Overall | .2110 | 1905-1913 | |
| 13 | Burt Hooton | .2111 | 1971-1978 | |
| 14 | Jeff Tesreau | .2114 | 1912-1918 | |
| 15 | Frank Tanana# | .2118 | 1974-1981 | |
| 16 | Rafael Jimenez# | .2126 | 1971-1981 | |
| 17 | Addie Joss | .2129 | 1902-1910 | |
| 18 | Jack Pfiester | .2135 | 1903-1911 | |
| 19 | Cy Morgan | .2139 | 1903-1913 | |
| 19 | Nolan Ryan# | .2139 | 1966-1981 | |
| 21 | Pete Richert | .2152 | 1962-1975 | |
| 22 | Dave Boswell | .2155 | 1964-1975 | |
| 23 | Ron Guidry# | .2160 | 1972-1981 | |
| 24 | Sam Jones | .2163 | 1951-1964 | |
| 25 | Walter Johnson* | .2168 | 1907-1927 | |
| 26 | Rube Waddell* | .2169 | 1897-1910 | |
| 26 | Frank E Smith | .2169 | 1904-1912 | |
| 28 | Jake Weimer | .2174 | 1903-1909 | |
| 29 | Bob Veale | .2175 | 1962-1974 | |
| 30 | Tommy Byrne | .2178 | 1943-1957 | |
| 31 | John D'Acquisto# | .2179 | 1972-1981 | |
| 32 | Luis Tiant | .2184 | 1964-1974 | |
| 33 | Don McMahon | .2190 | 1957-1971 | |
| 34 | Frank Riccelli# | .2191 | 1975-1981 | |
| 35 | Fred Beebe | .2192 | 1906-1916 | |
| 36 | Mordecai Brown* | .2197 | 1903-1916 | |
| 37 | Doc Scanlan | .2203 | 1903-1911 | |
| 38 | Tom Hall# | .2204 | 1968-1981 | |
| 39 | Blake Green# | .2209 | 1973-1981 | |
| 40 | Andy Messersmith# | .2210 | 1968-1981 | |
| 41 | Edwin Ramirez# | .2214 | 1976-1981 | |
| 41 | Larry Cheney | .2214 | 1911-1919 | |
| 43 | Carl Lundgren | .2216 | 1902-1909 | |
| 44 | Bob Feller* | .2217 | 1936-1956 | |
| 44 | Johnny Vander Meer | .2217 | 1937-1951 | |
| 46 | Harry Coveleski | .2223 | 1907-1918 | |
| 47 | Jim Scott | .2225 | 1909-1917 | |
| 48 | Victor Sanchez# | .2230 | 1976-1981 | |
| 49 | Sonny Siebert | .2231 | 1964-1973 | |
| 50 | Bob Gibson | .2232 | 1959-1979 | |
| 50 | Charles Bender* | .2232 | 1903-1925 | |
| 52 | Bobby Bolin | .2234 | 1961-1974 | |
| 53 | Tom Seaver | .2237 | 1967-1979 | |
| 54 | Al Downing | .2245 | 1961-1975 | |
| 55 | Ewell Blackwell | .2249 | 1942-1955 | |
| 56 | Bernie Boland | .2250 | 1915-1921 | |
| 57 | Barney Pelty | .2251 | 1903-1912 | |
| 57 | Ray Moore | .2251 | 1952-1963 | |
| 59 | Stan Williams | .2253 | 1958-1974 | |
| 59 | Mickey Lolich | .2253 | 1963-1978 | |
| 59 | Whitey Ford* | .2253 | 1950-1967 | |
| 59 | Luis Albo# | .2253 | 1974-1981 | |
| 63 | Reb Russell | .2255 | 1913-1919 | |
| 63 | Moe Drabowsky | .2255 | 1956-1972 | |
| 65 | Jim Maloney | .2256 | 1960-1974 | |
| 66 | Howie Camnitz | .2257 | 1904-1913 | |
| 67 | Lew Richie | .2259 | 1906-1913 | |
| 68 | Harry Harper | .2260 | 1913-1923 | |
| 69 | Vida Blue | .2261 | 1969-1979 | |
| 69 | George McQuillan | .2261 | 1907-1918 | |
| 71 | Jack Coombs | .2262 | 1906-1920 | |
| 71 | Tom Phoebus | .2262 | 1966-1976 | |
| 73 | Dean Chance | .2263 | 1961-1976 | |
| 74 | Steve Carlton# | .2265 | 1965-1981 | |
| 75 | Tim Keefe* | .2267 | 1880-1893 | |
| 75 | Nap Rucker | .2267 | 1907-1916 | |
| 77 | Allie Reynolds | .2268 | 1942-1954 | |
| 77 | Al Mamaux | .2268 | 1913-1924 | |
| 79 | Gary Nolan# | .2270 | 1967-1981 | |
| 80 | Dennis Leonard# | .2271 | 1971-1981 | |
| 81 | Mickey McDermott | .2272 | 1948-1961 | |
| 82 | Christy Mathewson* | .2273 | 1900-1916 | |
| 83 | Ray Culp | .2276 | 1963-1979 | |
| 84 | Phil Niekro# | .2278 | 1964-1981 | |
| 84 | J R Richard# | .2278 | 1971-1981 | |
| 84 | Jack Harshman | .2278 | 1945-1961 | |
| 87 | Fred Glade | .2279 | 1902-1908 | |
| 88 | Eddie Plank* | .2280 | 1901-1917 | |
| 89 | Bill Singer# | .2282 | 1964-1981 | |
| 89 | Earl Moore | .2282 | 1901-1913 | |
| 91 | Bill Donovan | .2283 | 1898-1918 | |
| 92 | Johnny Niggeling | .2285 | 1938-1946 | |
| 92 | Juan Marichal | .2285 | 1960-1974 | |
| 94 | Dick Stigman | .2288 | 1958-1967 | |
| 94 | Ferdie Schupp | .2288 | 1913-1922 | |
| 94 | Clay Kirby# | .2288 | 1969-1981 | |
| 94 | Vean Gregg | .2288 | 1911-1925 | |
| 98 | Eddie Fisher | .2291 | 1959-1971 | |
| 99 | Ken McBride | .2292 | 1959-1965 | |
| 99 | Rich Gossage | .2292 | 1972-1979 |
