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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Postseason Career Leaderboard |
|---|---|---|---|---|
| 1 | Christy Mathewson* | 0.000 | 1905 | |
| 1 | Old Hoss Radbourn* | 0.000 | 1884 | |
| 1 | Waite Hoyt* | 0.000 | 1921 | |
| 1 | Carl Hubbell* | 0.000 | 1933 | |
| 1 | Whitey Ford* | 0.000 | 1960 | |
| 1 | Duster Mails | 0.000 | 1920 | |
| 1 | Joe McGinnity* | 0.000 | 1905 | |
| 8 | Sandy Koufax* | 0.375 | 1965 | |
| 9 | Harry Brecheen | 0.450 | 1946 | |
| 10 | Bill Hallahan | 0.491 | 1931 | |
| 11 | Eddie Lopat | 0.500 | 1951 | |
| 11 | Hugh Bedient | 0.500 | 1912 | |
| 11 | Dick Rudolph | 0.500 | 1914 | |
| 11 | Rube Marquard | 0.500 | 1912 | |
| 11 | Spud Chandler | 0.500 | 1943 | |
| 11 | Gary Nolan# | 0.500 | 1971 | |
| 17 | Tim Keefe* | 0.514 | 1888 | |
| 18 | Luke Walker | 0.519 | 1970 | |
| 19 | Bob Moose# | 0.529 | 1970 | |
| 19 | Sherry Smith | 0.529 | 1920 | |
| 21 | Lon Warneke | 0.540 | 1935 | |
| 22 | Bob Veale | 0.600 | 1970 | |
| 22 | Ed Walsh* | 0.600 | 1906 | |
| 24 | Dave Foutz | 0.621 | 1885 | |
| 25 | Stan Coveleski* | 0.667 | 1920 | |
| 25 | Lew Burdette | 0.667 | 1957 | |
| 27 | George Earnshaw | 0.720 | 1930 | |
| 28 | Jack Stivetts | 0.931 | 1892 | |
| 29 | Christy Mathewson* | 0.942 | 1912 | |
| 30 | Mickey Lolich | 0.947 | 1971 | |
| 30 | Christy Mathewson* | 0.947 | 1913 | |
| 30 | Eddie Plank* | 0.947 | 1913 | |
| 33 | Orval Overall | 0.982 | 1908 | |
| 34 | Bob Gibson | 1.000 | 1967 | |
| 34 | Kid Nichols* | 1.000 | 1892 | |
| 34 | Orval Overall | 1.000 | 1907 | |
| 34 | Carl Mays | 1.000 | 1918 | |
| 34 | Johnny Podres | 1.000 | 1955 | |
| 34 | Nick Altrock | 1.000 | 1906 | |
| 34 | Hippo Vaughn | 1.000 | 1918 | |
| 34 | Paul Dean | 1.000 | 1934 | |
| 42 | Tommy John# | 1.038 | 1972 | |
| 42 | Charles Bender* | 1.038 | 1911 | |
| 44 | Babe Ruth* | 1.059 | 1918 | |
| 44 | Tom Seaver | 1.059 | 1972 | |
| 44 | Johnny Sain | 1.059 | 1948 | |
| 44 | Charles Bender* | 1.059 | 1905 | |
| 48 | Bullet Joe Bush | 1.080 | 1923 | |
| 48 | Jesse Haines | 1.080 | 1926 | |
| 48 | Nolan Ryan# | 1.080 | 1972 | |
| 51 | Gary Nolan# | 1.102 | 1975 | |
| 51 | Ed Halicki# | 1.102 | 1980 | |
| 53 | Tom Hall# | 1.125 | 1972 | |
| 53 | Mort Cooper | 1.125 | 1944 | |
| 53 | Whitey Ford* | 1.125 | 1957 | |
| 53 | John Clarkson* | 1.125 | 1885 | |
| 57 | Ray Culp | 1.174 | 1974 | |
| 57 | Lefty Tyler | 1.174 | 1918 | |
| 59 | Waite Hoyt* | 1.200 | 1926 | |
| 60 | Herb Pennock* | 1.227 | 1926 | |
| 61 | Pete Alexander* | 1.328 | 1926 | |
| 62 | Babe Adams | 1.333 | 1909 | |
| 63 | Jack Coombs | 1.350 | 1911 | |
| 63 | Red Ehret | 1.350 | 1890 | |
| 65 | Art Nehf | 1.385 | 1921 | |
| 65 | Bobo Newsom | 1.385 | 1940 | |
| 67 | Lefty Grove* | 1.421 | 1930 | |
| 67 | Dickey Kerr | 1.421 | 1919 | |
| 69 | Sam McDowell | 1.432 | 1977 | |
| 70 | Waite Hoyt* | 1.500 | 1928 | |
| 70 | Lady Baldwin | 1.500 | 1887 | |
| 70 | Marcos Ortega# | 1.500 | 1979 | |
| 70 | Bucky Walters | 1.500 | 1940 | |
| 70 | Mike Cuellar | 1.500 | 1969 | |
| 70 | Denny Galehouse | 1.500 | 1944 | |
| 70 | Lefty Gomez | 1.500 | 1937 | |
| 70 | Red Ruffing* | 1.500 | 1938 | |
| 70 | Sandy Koufax* | 1.500 | 1963 | |
| 79 | Tom Seaver | 1.514 | 1973 | |
| 80 | Pete Alexander* | 1.528 | 1915 | |
| 80 | Ernie Shore | 1.528 | 1916 | |
| 82 | Dick Ruthven# | 1.543 | 1977 | |
| 83 | Jim Bouton | 1.558 | 1964 | |
| 83 | Willie Hernandez# | 1.558 | 1978 | |
| 85 | Eddie Cicotte | 1.565 | 1917 | |
| 86 | Vic Raschi | 1.588 | 1952 | |
| 86 | Eddie Plank* | 1.588 | 1905 | |
| 86 | John D'Acquisto# | 1.588 | 1974 | |
| 89 | Jesse Barnes | 1.653 | 1921 | |
| 89 | Bob Lemon | 1.653 | 1948 | |
| 91 | Mickey Lolich | 1.667 | 1968 | |
| 91 | Dave McNally# | 1.667 | 1969 | |
| 91 | Bob Gibson | 1.667 | 1968 | |
| 94 | Bill Donovan | 1.714 | 1907 | |
| 95 | Carl Mays | 1.731 | 1921 | |
| 95 | Dizzy Dean* | 1.731 | 1934 | |
| 97 | Max Lanier | 1.761 | 1943 | |
| 98 | Allie Reynolds | 1.770 | 1952 | |
| 99 | Dick Drago# | 1.776 | 1980 | |
| 100 | Doc White | 1.800 | 1906 |
