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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K9 | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Stan Benjamin | 11.27 | 1940 | |
| 2 | Sam McDowell | 10.71 | 1965 | |
| 3 | Sandy Koufax* | 10.55 | 1962 | |
| 4 | Sam McDowell | 10.42 | 1966 | |
| 5 | Sandy Koufax* | 10.24 | 1965 | |
| 6 | Sandy Koufax* | 10.13 | 1960 | |
| 7 | Nolan Ryan# | 10.06 | 1970 | |
| 8 | Sam McDowell | 10.04 | 1970 | |
| 9 | Blake Green# | 10.01 | 1980 | |
| 10 | Dave Righetti# | 9.89 | 1980 | |
| 11 | Victor Sanchez# | 9.85 | 1978 | |
| 12 | Victor Sanchez# | 9.82 | 1979 | |
| 13 | Dirceu Miro# | 9.76 | 1980 | |
| 14 | Victor Sanchez# | 9.71 | 1977 | |
| 15 | Herb Score | 9.70 | 1955 | |
| 16 | Tom Hall# | 9.64 | 1972 | |
| 17 | Tony Guzman# | 9.61 | 1980 | |
| 18 | Tom Griffin# | 9.56 | 1969 | |
| 19 | Jim Maloney | 9.53 | 1963 | |
| 20 | Herb Score | 9.49 | 1956 | |
| 21 | Sandy Koufax* | 9.47 | 1961 | |
| 21 | Sam McDowell | 9.47 | 1968 | |
| 23 | Victor Sanchez# | 9.44 | 1976 | |
| 24 | Marcos Ortega# | 9.40 | 1977 | |
| 24 | Don Wilson# | 9.40 | 1969 | |
| 26 | Nolan Ryan# | 9.37 | 1971 | |
| 27 | Victor Rose# | 9.36 | 1977 | |
| 28 | Bob Veale | 9.34 | 1965 | |
| 29 | Mickey Lolich | 9.33 | 1970 | |
| 30 | J R Richard# | 9.31 | 1976 | |
| 31 | Luis Tiant | 9.22 | 1967 | |
| 32 | Luis Tiant | 9.20 | 1968 | |
| 33 | Dave Boswell | 9.19 | 1966 | |
| 33 | Sam McDowell | 9.19 | 1964 | |
| 35 | Marcos Ortega# | 9.12 | 1981 | |
| 36 | Sonny Siebert | 9.11 | 1965 | |
| 37 | Nolan Ryan# | 9.08 | 1977 | |
| 38 | Sam McDowell | 9.03 | 1972 | |
| 38 | Red Embree | 9.03 | 1944 | |
| 40 | Sammy Ellis | 9.00 | 1963 | |
| 40 | Sandy Koufax* | 9.00 | 1964 | |
| 42 | Sam McDowell | 8.99 | 1967 | |
| 43 | Vida Blue | 8.98 | 1970 | |
| 43 | Nolan Ryan# | 8.98 | 1978 | |
| 45 | Dirceu Miro# | 8.92 | 1981 | |
| 45 | Jim Maloney | 8.92 | 1964 | |
| 47 | Marcos Ortega# | 8.89 | 1980 | |
| 48 | Nolan Ryan# | 8.88 | 1972 | |
| 49 | Sandy Koufax* | 8.86 | 1963 | |
| 50 | J R Richard# | 8.85 | 1975 | |
| 51 | Sandy Koufax* | 8.83 | 1966 | |
| 51 | Sam McDowell | 8.83 | 1974 | |
| 53 | Tom Hall# | 8.82 | 1973 | |
| 54 | Sam McDowell | 8.81 | 1969 | |
| 55 | J R Richard# | 8.80 | 1977 | |
| 56 | Nolan Ryan# | 8.77 | 1975 | |
| 57 | Al Downing | 8.76 | 1963 | |
| 57 | Lowell Palmer | 8.76 | 1972 | |
| 59 | Bob Moose# | 8.74 | 1969 | |
| 60 | Marcos Ortega# | 8.71 | 1978 | |
| 60 | Rod Scurry# | 8.71 | 1979 | |
| 62 | Vinny Mendoza# | 8.69 | 1979 | |
| 62 | Vinny Mendoza# | 8.69 | 1980 | |
| 62 | Juan Pizarro | 8.69 | 1961 | |
| 62 | Mickey Lolich | 8.69 | 1969 | |
| 66 | Hugh Daily | 8.68 | 1884 | |
| 67 | Victor Rose# | 8.67 | 1978 | |
| 67 | Nolan Ryan# | 8.67 | 1976 | |
| 69 | Nolan Ryan# | 8.66 | 1974 | |
| 70 | Ronnie Sims# | 8.65 | 1978 | |
| 70 | Jim Maloney | 8.65 | 1966 | |
| 70 | Marcos Ortega# | 8.65 | 1979 | |
| 73 | Jim Maloney | 8.60 | 1965 | |
| 73 | Nolan Ryan# | 8.60 | 1973 | |
| 75 | Michael Steen# | 8.58 | 1981 | |
| 75 | Rafael Jimenez# | 8.58 | 1980 | |
| 75 | Vinny Mendoza# | 8.58 | 1978 | |
| 75 | Victor Rose# | 8.58 | 1976 | |
| 79 | Ted Wills | 8.56 | 1963 | |
| 80 | Sammy Ellis | 8.55 | 1962 | |
| 81 | Dick Selma | 8.54 | 1969 | |
| 81 | Dave Righetti# | 8.54 | 1981 | |
| 83 | Nolan Ryan# | 8.53 | 1979 | |
| 83 | Dick Stigman | 8.53 | 1959 | |
| 85 | Steve Shields# | 8.50 | 1981 | |
| 85 | Rudy May | 8.50 | 1972 | |
| 87 | Bob Veale | 8.49 | 1969 | |
| 88 | Hal Newhouser | 8.46 | 1946 | |
| 89 | Sam McDowell | 8.45 | 1973 | |
| 89 | Rafael Jimenez# | 8.45 | 1981 | |
| 91 | Bob Feller* | 8.43 | 1946 | |
| 91 | Adrian Wolf# | 8.43 | 1977 | |
| 91 | Lowell Palmer | 8.43 | 1968 | |
| 94 | Blake Green# | 8.42 | 1975 | |
| 95 | Tom Seaver | 8.41 | 1971 | |
| 95 | Tom Deidel# | 8.41 | 1976 | |
| 97 | Sam McDowell | 8.40 | 1975 | |
| 97 | Sam Jones | 8.40 | 1956 | |
| 99 | Rube Waddell* | 8.39 | 1903 | |
| 100 | Adrian Wolf# | 8.37 | 1980 |
