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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | IP | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Cy Young* | 7354.0 | 1890-1911 | |
| 2 | Pud Galvin* | 6003.0 | 1875-1892 | |
| 3 | Walter Johnson* | 5914.0 | 1907-1927 | |
| 4 | Warren Spahn* | 5243.0 | 1942-1965 | |
| 5 | Jim Kaat | 5197.0 | 1959-1979 | |
| 6 | Pete Alexander* | 5190.0 | 1911-1930 | |
| 7 | Kid Nichols* | 5056.0 | 1890-1906 | |
| 8 | Tim Keefe* | 5047.0 | 1880-1893 | |
| 9 | Bob Gibson | 5029.0 | 1959-1979 | |
| 10 | Bobby Mathews | 4956.0 | 1871-1887 | |
| 11 | Mickey Welch | 4802.0 | 1880-1892 | |
| 12 | Christy Mathewson* | 4780.0 | 1900-1916 | |
| 13 | Robin Roberts* | 4688.0 | 1948-1966 | |
| 14 | Dave McNally# | 4669.0 | 1962-1981 | |
| 15 | Early Wynn* | 4564.0 | 1939-1963 | |
| 16 | John Clarkson* | 4536.0 | 1882-1894 | |
| 17 | Old Hoss Radbourn* | 4535.0 | 1881-1891 | |
| 18 | Tony Mullane | 4531.0 | 1881-1894 | |
| 19 | Eppa Rixey* | 4494.0 | 1912-1933 | |
| 20 | Fergie Jenkins# | 4473.0 | 1965-1981 | |
| 21 | Catfish Hunter# | 4429.0 | 1965-1981 | |
| 22 | Jack J Powell | 4389.0 | 1897-1912 | |
| 23 | Red Ruffing* | 4344.0 | 1924-1947 | |
| 24 | Gus Weyhing | 4324.0 | 1887-1901 | |
| 25 | Tommy John# | 4287.0 | 1963-1981 | |
| 26 | Jim McCormick | 4275.0 | 1878-1887 | |
| 27 | Eddie Plank* | 4227.0 | 1901-1917 | |
| 28 | Don Sutton# | 4217.0 | 1966-1981 | |
| 29 | Sam McDowell | 4188.0 | 1961-1979 | |
| 30 | Burleigh Grimes* | 4180.0 | 1916-1934 | |
| 31 | Ted Lyons* | 4161.0 | 1923-1946 | |
| 32 | Denny McLain# | 4157.0 | 1963-1981 | |
| 33 | Gaylord Perry | 4101.0 | 1962-1978 | |
| 34 | Red Faber* | 4086.0 | 1914-1933 | |
| 35 | Vic Willis | 3996.0 | 1898-1910 | |
| 36 | Gary Nolan# | 3980.0 | 1967-1981 | |
| 37 | Lefty Grove* | 3940.0 | 1925-1941 | |
| 38 | Sad Sam Jones | 3883.0 | 1914-1935 | |
| 39 | Larry Dierker# | 3830.0 | 1964-1981 | |
| 40 | Bob Feller* | 3827.0 | 1936-1956 | |
| 41 | Clay Kirby# | 3802.0 | 1969-1981 | |
| 42 | Amos Rusie | 3769.0 | 1889-1901 | |
| 43 | Waite Hoyt* | 3762.0 | 1918-1938 | |
| 44 | Bobo Newsom | 3759.0 | 1929-1953 | |
| 45 | Mickey Lolich | 3736.0 | 1963-1978 | |
| 46 | Phil Niekro# | 3707.0 | 1964-1981 | |
| 47 | Ken Holtzman# | 3689.0 | 1965-1981 | |
| 48 | Jim Bunning | 3671.0 | 1955-1973 | |
| 49 | Andy Messersmith# | 3649.0 | 1968-1981 | |
| 50 | Paul Derringer | 3645.0 | 1931-1945 | |
| 51 | Tommy Bond | 3628.0 | 1874-1884 | |
| 52 | Milt Pappas | 3624.0 | 1957-1976 | |
| 53 | Bob Friend | 3611.0 | 1951-1966 | |
| 54 | Carl Hubbell* | 3590.0 | 1928-1943 | |
| 55 | Mel Stottlemyre Sr# | 3588.0 | 1964-1981 | |
| 56 | Herb Pennock* | 3571.0 | 1912-1934 | |
| 57 | Earl Whitehill | 3564.0 | 1923-1939 | |
| 58 | Will White | 3542.0 | 1877-1886 | |
| 59 | Adonis Terry | 3514.0 | 1884-1897 | |
| 60 | Jim Whitney | 3496.0 | 1881-1890 | |
| 61 | Tom Seaver | 3494.0 | 1967-1979 | |
| 62 | Wilbur Cooper | 3480.0 | 1912-1926 | |
| 63 | George Mullin | 3451.0 | 1902-1913 | |
| 64 | Joe McGinnity* | 3441.0 | 1899-1908 | |
| 65 | Dick Drago# | 3433.0 | 1969-1981 | |
| 66 | Don Drysdale* | 3432.0 | 1956-1969 | |
| 67 | Mel Harder | 3426.0 | 1928-1947 | |
| 68 | Charlie Buffinton | 3404.0 | 1882-1892 | |
| 69 | Hooks Dauss | 3390.0 | 1912-1926 | |
| 70 | Clark Griffith* | 3385.0 | 1891-1914 | |
| 71 | Jim Nash | 3381.0 | 1966-1980 | |
| 72 | Chick Fraser | 3356.0 | 1896-1909 | |
| 73 | Al Orth | 3354.0 | 1895-1909 | |
| 74 | Bill Hands# | 3349.0 | 1965-1981 | |
| 75 | Curt Simmons | 3348.0 | 1947-1967 | |
| 76 | Bob Moose# | 3308.0 | 1967-1981 | |
| 77 | Rube Marquard | 3306.0 | 1908-1925 | |
| 77 | Billy Pierce | 3306.0 | 1945-1964 | |
| 79 | Jack Quinn | 3304.0 | 1909-1933 | |
| 80 | Jim Palmer | 3303.0 | 1965-1981 | |
| 81 | Juan Marichal | 3294.0 | 1960-1974 | |
| 82 | Bill Singer# | 3287.0 | 1964-1981 | |
| 83 | Larry Jackson | 3262.0 | 1955-1968 | |
| 84 | Gary Peters | 3236.0 | 1959-1975 | |
| 85 | Dick Bosman# | 3223.0 | 1966-1981 | |
| 85 | Freddie Fitzsimmons | 3223.0 | 1925-1943 | |
| 85 | Eddie Cicotte | 3223.0 | 1905-1920 | |
| 88 | Dolf Luque | 3220.0 | 1914-1935 | |
| 89 | Dutch E Leonard | 3218.0 | 1933-1953 | |
| 90 | Jesse Haines | 3208.0 | 1918-1937 | |
| 91 | Red Ames | 3198.0 | 1903-1919 | |
| 92 | Charlie Root | 3197.0 | 1923-1941 | |
| 93 | Silver King | 3190.0 | 1886-1897 | |
| 94 | Whitey Ford* | 3170.0 | 1950-1967 | |
| 95 | Lee Meadows | 3160.0 | 1915-1929 | |
| 96 | Larry French | 3152.0 | 1929-1942 | |
| 97 | Nolan Ryan# | 3146.0 | 1966-1981 | |
| 98 | Jerry Koosman | 3129.0 | 1967-1981 | |
| 99 | Tom Zachary | 3126.0 | 1918-1936 | |
| 100 | George Uhle | 3119.0 | 1919-1936 |
